Wednesday, November 26, 2014

How Would CRISP Help Patients of Chronic Rhinosinusitis ?

How Would CRISP Help Patients of Chronic Rhinosinusitis ?

Recently, Geisinger Health System, John Hopkins Bloomberg School of Public Health, the Northwestern Medicine® Sinus and Allergy Centre, and the University of Chicago formed Chronic Rhinosinusitis Integrative Studies Program (CRISP) in the United States of America. The collective program would conduct research studies to understand the disease and develop effective methods of the treatment, benefiting the patients. CRISP received the program project grant (P01) to study the disease that is common in America but current knowledge of which is still rudimentary. The program would estimate remission, prevalence, and incidence of chronic rhinosinusitis (CRS) based on studies involving samples from general population representing the complete CRS spectrum.

Goals of Chronic Rhinosinusitis Integrative Studies Program

  • To understand genetic polymorphism associated with severity and susceptibility of CRS
  • To find costs and characteristics of the disease
  • To identify the factors exacerbating stubborn CRS
  • How do immunological factors affect CRS?
  • To study environmental risks of the disorder

Composition of Chronic Rhinosinusitis Integrative Studies Program


CRISP consists of five groups of collaborative studies and research work:
Core A focuses on administration.
Core B, Clinical, Laboratory, and Data Management Core
CRS Epidemiology Project: The Geisinger Health Systems (G.H.S.) would use new approaches to appraise epidemiology of the disease in more than 300,000 primary care patients in Pennsylvania.
CRS Immunology and Exacerbation Mechanism Project would collaborate with the epidemiology project at Northwestern University (1) to study the pathogens exacerbating the disease and (2) to define scope of autoimmunity in severity of the disease. The immunology project would also assess the role of autoimmunity and B lineage cells in the CRS etiology. 
CRS Genetics Project: The University of Chicago would conduct research studies (1) to find genes associated with the disease and (2) to understand relationship between the genetics and severity and various states of the disorder. The university would use the epidemiology project controls and samples collected from 2,000 patients to understand the genetics. 
The epidemiology and immunology projects would develop a new “systems genetics discovery platform” that would be used for identifying gene candidates.

Benefits of CRISP

The resultant improved fundamental knowledge about sub-phenotypes of CRS would help researchers in identifying cellular and molecular mechanisms and genetic susceptibilities causing and exacerbating the symptoms of the disease.  The understanding would facilitate development of therapies that are more effective than the existing ones.

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