Thursday, June 27, 2013

CYCLAMEN EXTRACT definition

CYCLAMEN EXTRACT definition



Cyclamen extract is a nasal spray used for the relief of nasal congestion (blocked up feeling in your nose), nasal secretions, loss of smell and facial pain by clearing and draining the mucous secretions retained in sinuses (passages leading to the nose), nasal cavities and upper respiratory tract, providing fast symptom relief from the very first dose.
When you use cyclamen extract you will experience an intense discharge of dammed up secretions from the nose and paranasal cavities, which can last up to two hours. As a result, the headache or facial pain, which often accompanies nasal congestion, rapidly ceases. 
In cases of otitis media, the dammed up secretions are rapidly eliminated, resulting in a decrease of earache and recovery of hearing loss.




Composition

A lyophilized powder which is obtained from a natural extract of fresh tubers of Cyclamen europaeum L. 
Excipients:
There are neither artificial ingredients nor preservatives. 
A solvent (5 ml of water) is provided for reconstitution of the lyophilized powder.

Chemical composition and properties
Cyclamen is a member of the primrose family (Primulaceae) and it has been used medicinally since ancient times. As example, Theophrastus, in Ancient Greece (4th-3rd centuries BC), recommended inserting a mixture of cyclamen extract and honey into the nose for the treatment of nasal catarrh and headaches (“to clear the head”).
Nasodren® is an extract of Cyclamen europaeum L. that contains triterpenic saponins that acting as a local surfactant on the mucous membranes to promote the intranasal drainage of fluid from the sinuses through a physical mechanism. The superficial physical impact is converted into a change in electric potential by reversible stretching of the terminal axonal membrane. These events are closely similar to physiologic responses in stretch or tactile receptors elsewhere in the body.

Friday, June 21, 2013

Study in Chronic rhinosinusitis 2013

Study in Chronic rhinosinusitis 2013



The study coordinators are, Dr. A. S. Lopatin, president of the Russian Rhinology Society and Dr. G. Z. Piskunov, associate member of the Russian Academy of Medical Sciences.
The objective of this study is to obtain data to improve both knowledge and the treatment of chronic rhinosinusitis.



Within the performance of the project, 4 stages are planned:

Stage I: Cross-sectional analytical multicentre study using randomized individual standardized interview (questionnaire) “Conventional practice of chronic rhinosinusitis treatment in Russia”. 
Multicentre doctors questionnaire of E.N.T. specialists from different regions of Russia.  It is planned to obtain about 800 questionnaires



Stage II:  “Multicentre observational epidemiologic study with the aim of studying the efficacy and safety of treatment regimens for patients with chronic rhinosinusitis exacerbation”. This non-interventional observational prospective epidemiologic study is focused on the examination of chronic rhinosinusitis exacerbation treatment practice by means of evaluating clinical outcomes, treatment regimens and treatment cost. Evaluation lasts up to 6 months after patient inclusion.
Eighteen centres from all over Russia participate in the study, with 21 patients from each centre. During the follow-up period the attending medical doctor performs treatment and monitoring of patients according to established standard clinical practice.


Monitoring plan. 
During this non-interventional prospective epidemiologic study, data for 5 time periods are to be registered. Patients are randomly allocated to one of the treatment regimens included in the study.

When chronic exacerbations occur, the different treatment regimens being followed, together with their outcomes, are assessed.
All values of treatment results, treatment changes and volume of additional diagnostic interventions are fully registered in CRF for analysis of clinical outcomes in patients with chronic rhinosinusitis exacerbation.
Stage III: “Study of the spectrum of bacterial causative organisms associated with chronic rhinosinusitis”.

The aim is to examine the spectrum of microorganisms (aerobic and anaerobic) in the contents of the maxillary sinus cavity in patients with chronic rhinosinusitis, and also to study their susceptibility and resistance to different antimicrobial drugs.
Material sampling during maxillary sinus cavity paracentesis is performed in 4 clinical centres.
Each centre selects 40 patients (Each centre in Moscow selects 20 patients). In the study, patients of both genders will participate with symptoms of “chronic rhinosinusitis” present. During two-sided process, material for cultural study is withdrawn separately from each maxillary sinus cavity.
All tubes with biological material are transferred and analysed in, Smolensk State Medical Academy.



Stage IV: “Incidence of nasal and paranasal sinus diseases in Russia”. Questionnaire: respondents are adult population (patients visiting ambulatory clinic for health assessment (ENT focus), medical institution specialists, medical university students, patients visiting clinic for reasons not associated with ENT- specialisation).  
Survey of 3,000 people is planned.
All stages are performed concomitantly.
Report of the final results for the “CHRONOS” project is expected around the end of 2013. 

Friday, June 14, 2013

Can Nasodren® be used after surgery?

Can Nasodren® be used after surgery?


 
The study “Dynamics of the transport and heating function indices of the mucous membrane of the nasal cavity in the early postoperative management of patients with chronic rhinosinusitis” (Popovich VI, Staiden EB, Savchuck OI, Ukranian Rhinology, 2007; (3) 56-62), which included 110 patients with chronic sinusitis, demonstrated that the early postoperative management approach involving the use of Cyclamen extract results in an earlier normalization of the major physiological functions of the nasal cavity. Thus, Cyclamen extract provides rapid relief from "acute postoperative sinusitis". The study also concluded that the use of Cyclamen extract is safe and free from undesirable side effects.


Thursday, June 6, 2013

Does Cyclamen extract work for otitis?

Does Cyclamen extract work for otitis?



Sinusitis and otitis are related medical conditions because the paranasal sinuses and ears are located close to each other in the skull. Ear or facial pain is a typical symptom of sinus infection. If the sinusitis patient bends forward, ear pain or sinus pressure may increase. Sinusitis is a disease of the sinuses, whereas otitis means an infection or inflammation of the ear. The ear is divided into three parts: outer, middle and inner. The corresponding infections are medically referred to as otitis externa, otitis media and otitis interna.
Acute otitis media (AOM) is analogous to acute sinusitis in that it is a result of obstruction at the ostium of the Eustachian tube.

Administration of the Cyclamen extract-based preparation is effective in the treatment of secretory otitis media; it shortens the treatment time and avoids the use of aggressive therapies, such as myringotomies, in these patients
The Cyclamen europaeum effect on the mucous membrane of the nasal cavity, the nasopharynx and the paranasal sinuses causes an intense reflex secretion. This secretion causes intense drainage of the nasal cavity and the paranasal sinuses, resulting in increased activity of the ciliated epithelium in the Eustachian tube and exudate evacuation from the tympanic cavity of the middle ear.


The study “Use of Sinuforte® in the management of acute rhinosinusitis and secretory otitis in children” (Berezniuk VV, Chernokur AA; Journal Otorhinolaryngological Disease. 2006; (2): 65-68), concludes that the use of the preparation Sinuforte® in the combined symptomatic treatment of acute rhinosinusitis, accompanied by secretory otitis, results in rapid relief of the inflammatory process in the nasal cavity, the paranasal sinuses and the middle ear. It led to the achievement of stable positive results in the symptomatic treatment of this pathology for 96.7% of the study group patients.
Sinuforte®/Nasodren® in combination with antibiotics considerably reduces the amount of recurrences and their frequency.
The clinical effectiveness of Sinuforte®/Nasodren® in monotherapy of chronic rhinosinusitis is comparable to the effect of the therapy with antibiotics.

The received data supports a reduction in the frequency of prescribing antibiotics when patients have recurring exacerbation of rhinosinusitis, favouring the prescription of Sinuforte®/Nasodren® in monotherapy and thus reducing polypharmacy.