Thursday, May 30, 2013

Microendoscopy Study results

Study of specific microendoscopic characteristics of intranasal mucosa in patients presenting with chronic rhinosinusitis and treated with Sinuforte

Key messages from this study
  • Sinuforte is safe and efficacious for the treatment of patients with Chronic Rhinusitis (CRS)
  • Sinuforte improves drastically the most frequent symptoms of CRS (facial pain and nasal congestion)
  • Sinuforte alleviate rhinosinusitis symptoms from the first application
  • Subjective improvements correlate with objective findings
  • Sinuforte physiologically resolves CRS exacerbation without disrupting the anatomical integrity of the nasal mucosa
  • Tolerance of Sinuforte is rated as excellent or good for both patients and researchers
Study: Randomized open clinical and instrumental study with a control group
Objective: to assess the efficacy of the treatment of chronic rhinosinusitis (CRS) in the patients treated with Sinuforte using the contact microendoscopic technique.
Patients: 30 patients diagnosed with CRS, based on clinical observation, endoscopic and microendoscopic examination of intranasal mucosa and functional tests, in accordance with the EPOS 2007 (European Position Paper on Rhinosinusitis and Nasal Polyps).

Study methods: basic criteria for inclusion were: exacerbated CRS of moderate severity and absence of gross deformations of intranasal anatomical structures.

Effectiveness of treatment was evaluated using a questionnaire, instrumental examination (endoscopic and microendoscopic), and functional tests (laser Doppler flowmetry) on day 1 of the study, and also on days 2, 4, 6, and 8 after the start of treatment. 



Results: clinical and instrumental data on treatment with Sinuforte revealed improvement of general and/or local CRS symptoms, as confirmed by data from contact microendoscopy, in 30 patients (100%).

Tolerance of the Cyclamen extract was evaluated as “good” in 100% of cases by patients and the researcher using a point scale. Tolerance at the end of the course of treatment was evaluated as “good” in 90% of cases and “excellent” in 10% of cases. There were no unsatisfactory evaluations.
The efficacy of Sinuforte was evaluated cumulatively after phased treatment, taking into account the dynamics of subjective and clinical parameters at each visit as “good” by day 4 and as “excellent” by day 8.

M. A. KHOROL´SKAYA, S. G. VAKHRUSHEV, N. V. TERSKOVA.
Vestn Otorinolaringol 2011; 5: 59

Friday, May 24, 2013

Is Nasodren® effective in the case of halitosis?

Is Nasodren® effective in the case of halitosis?

Halitosis (bad breath) is mostly caused by sulphur-producing bacteria that normally live on the surface of the tongue and in the throat. About 2.4% of the adult population suffers from bad breath.
Apart from the sulphur-producing bacteria that colonise the back of the tongue, the other major causes of halitosis are:
  • Dental factors – such as periodontitis (infection around the teeth) or poor oral hygiene
  • Dry mouth – caused by medicines, alcohol, stress or a medical condition
  • Smoking – which starves the mouth of oxygen.
  • Rhinosinusitis

When there is a problem in a sinus, bad breath is the result of some basic factors: drainage from the sinus runs towards the back of the oesophagus and onto the very back of the tongue. This drainage is a rich source of protein containing sinus cells that have sloughed off, blood cells, pus cells and additional molecules formed by the body. These components act as ideal nutrients for the oral bacteria. With a balanced, continuous food supply from sinus drainage, bad breath is boosted by the growing population of bacteria.
Bad breath caused by sinus drainage is not just a warning sign of sinusitis, but also a situation in which the sinuses become unhygienic or swollen. It can occur as a result of a viral infection, similar to the case of colds, or due to allergens, as in the case of allergies. At times, sinusitis may be associated to asthma attacks. Whatever the reason is, sinusitis usually brings on bad breath as a result of sinus drainage.
Whenever a person suffers from sinusitis, the coating of mucus in the sinuses is aggravated and begins to generate too much mucus. A normal person generates mucus on a regular basis to maintain the nasal passages hygienic and clear. On the other hand, when these mucous coatings are aggravated, they go on overdrive and generate excessive mucus, resulting in a general sinusitis symptom called postnasal drip, which could lead to bad breath.




In addition, the disease causing sinusitis may perhaps also cause swelling of the nasal passages. The nasal passages join the nose, via your sinuses, to allow air into the lungs. When these nasal passages are swollen it results in accumulation of mucus. Thus, the mucus gets ensnared inside these nasal passages, catching the attention of bacteria, which flourish in dark, wet places.
So, when halitosis is caused by rhinosinusitis, Nasodren® will help to eliminate it.

Wednesday, May 8, 2013

Case experience

POSTOPERATIVE CARE, Case experience



My observational experience in postoperative care with cyclamen extract is based above all on 28 patients who underwent ethmoidectomies for polyposis. In 14 cases, saline irrigations were used, while in the remaining 14, a cyclamen extract was administered intranasally
in addition to the irrigations. One spray was administered into each nostril, once a day. The treatment was started on the third day after withdrawing Merocel. The patients treated with the cyclamen extract
experienced a significant improvement in the evolution of the cavities after the sixth day of the postoperative period (third day of treatment).
Only one case of frontal pain caused by frontal sinusitis, requiring discontinuation of the treatment, has been documented.
The endoscopic images of the nasal passages of a case of sinonasal polyposis with superinfection show how abundant mucus from the
maxillary sinus appears only a few minutes after administration of this product. In the patients treated with cyclamen extract, the maxillary sinus is clear after 48 hours, due to the product’s self-cleansing effect. 
By the 4th day after starting treatment, recovery of the affected area is obvious. By the 6th day, there is a clear retention of the mucosal oedema (when normally this happens after 10-12 days); this effect could be due to use of this preparation.
The side effects observed with this product are limited to a smarting sensation during the first few sprays, which is variable or even absent in operated patients. Other side effects may be sneezing and watery rhinorrhoea.
Generally speaking, these effects are mild, transient, expected, rare, with minimal clinical significance.





REMARKS
Treatment can be started on the day after surgery or when the tamponade is removed and there is no risk of bleeding.
The reason for using Cyclmen extract only once a day is basically because it induces a very strong expression of mucoid cells. Consequently, readministering after 12 hours would not provide any significantly greater benefit than that obtained by administering every 24 hours.
This treatment can be continued without problems for more than a week. Since it causes no significant adverse effects, it can be used for up to 10-15 days.
Cyclamen extract may be useful in all patients who require postoperative care, provided that there is healthy mucosa. Its effect would be very limited in those cases where the entire mucous membrane has been removed.
The main contraindication for this product is that it should not be used in patients with obstruction.
This treatment can be repeated as often as is wished, and can be stopped when the patient wishes.

CONCLUSION
It is my opinion that it will be very useful in clearing the surgical cavity, it will reduce the need for aggressive postsurgical wound treatments, the time between treatments of the surgical area will be longer, it will facilitate self-cleansing, it will possibly speed up the reepithelialisation process, and will enable topical corticoids to be applied earlier.



Take it from:
THERAPEUTICS AND CLINICAL RISK
MANAGEMENT
Personal observation of Dr. H. Massegur 
Spain.

Thursday, May 2, 2013

Cyclamen extract and acute rhinosinusitis aspect

Cyclamen extract and acute rhinosinusitis aspect


In acute rhinosinusitis, the nasal sinuses are blocked and significant inflammation is reported ; the mucosa is swollen and the exudate accumulates within the sinuses, causing mucopurulent secretions.
Cyclamen extract acts on the sinonasal mucosa , inducing a strong reflex secretion that rapidly leads to the discharge of abundant mucus. The retained seromucous secretions are expelled, thereby reducing or eliminating tissue congestion and oedema. Cyclamen extract effectively opens the nasal spaces, facilitating physiological drainage and clearing of the nasal cavities. With this treatment, the underlying cause of the rhinosinusitis is eradicated and the respirator y mucosa regenerates physiologicall y in just a few days. The treatment offers an extensive range of benefits and it is possible to prevent or even treat a serous otitis media by improving ventilation of the Eustachian tube and the middle meatus.




  • Cyclamen europaeum has been shown to be highly effective as a single-agent therapy in 56% of the patients treated for acute rhinosinusitis . All of these patients had a drainage orifice.


• In 21% of the patients, a partial blockage of the orifice associated with inflam - mation of the sinonasal mucosa was observed, for which systemic decongestants were prescribed.

•And in 23% of the patients, the blockage was complete . These patients had severe rhinosinusitis and required treatment with antibiotics .

• By the 10th day of treatment, a marked clinical recovery was observed.

Prof. Vasil Ivanovich Popovich
PRESENT AND FUTURE OF THE MANAGEMENT OF SINONASAL DISEASEMADRID, 11 NOVEMBER 2007