Tuesday, February 26, 2013

Use of a new plant extract based product in inflammatory diseases of the paranasal sinuses.

Use of a new plant extract based product in inflammatory diseases of the paranasal sinuses.

The incidence of rhinosinusitis continues to increase year after year, in spite of the therapies
currently available. Although antibiotics have been used extensively for the treatment of rhinosinusitis,
their insufficient efficacy has sometimes contributed to aggravating the problem,
as their indiscriminate use eliminates vital saprophytic flora and leads to the creation of
strains that are resistant to antibiotics. This hasled several authors to reflect on the need for a
more rational use of the medication currently used in the treatment of rhinosinusitis.

In recent years, a product has been developed which, when applied in the nasal cavity, activates
the physiological nasal mucosa clearing mechanisms, promoting natural secretion,
cleansing and drainage of the accumulated purulent content. Our purpose was to analyse
this new plant extract-based product’s effect on rhinosinusitis. Computerised axial tomographies
were obtained from 50 patients. The results of our study indicate that the plant extracts promote effective drainage of the retained secretions in rhinosinusitis, thereby facilitating
symptom relief for the patient.


In spite of the considerable interest that has existed from some years now in the treatment of rhinosinusitis, there still exists a significant percentage of patients who suffer complications, sometimes rendering necessary drainage of the
mucus or even sinus punctures. However, in spite of these treatments, this condition sometimes
becomes chronic, giving rise to severe discomfort for the patient and is the cause of
a significant number of days lost from work or school (Piskunov 1995; Henriksson et al. 1996; Pluzhnikov 2003).

Although various methods are currently available for the treatment of acute suppurative
rhinosinusitis, traditionally the treatments prescribed have sought to eradicate the causal
agents of the inflammation, focusing on removing the suppuration from the sinuses,
combined with treatment with antibiotics and vasoconstrictive antihistamine preparations.
However, the insufficient efficacy associated with these treatments has led to a greater trend
towards relapses and chronification, which in turn has raised the need to continue researching
in this field. In recent years, further data have appeared that confirm the ineffectiveness of
treatment with antibiotics in certain situations (Barreiro et al. 2002). Indeed, by eliminating
the indispensable saprophytic flora and generating resistant bacterial strains, antibiotics
can worsen the problem in certain cases. Furthermore,many of the antibiotics commonly
used today have an immunosuppressive action (Pluzhnikov 2003). This has led several authors
to reflect on the need for a more rational use of the conventional therapy for sinusitis so that
the resources currently available can be used more suitably, given their limited efficacy and
the not insignificant presence of adverse effects (Lopatin 1992; Werk & Bauchner 1998; Turnidge
2001; Varonen & Sainio 2004).

Consequently, the use of a natural product for draining accumulated secretions that also propitiates
relief of the symptoms caused by the congested mucosa may be highly useful. This
new product with plant extracts is effective in draining secretions while it has few side effects.
Our results indicate that its action on the nasal mucosa facilitates a reflex secretion and, by activating
physiological mechanisms, it is able to naturally and effectively clear the retained secretions.
This data has been confirmed in other studies, which showed an efficacy rate greater
than 90% in eliminating the main symptoms of rhinosinusitis (difficulty in nasal breathing,
decrease and/or disappearance of pathological secretions, disappearance of headache and
tenderness, among others) (Zasritskaia et al. 2006; Chernisheva & Siniachenko 2006). Furthermore,
being a natural product, the likelihood of adverse effects and allergic reactions
is minimal. In fact, the incidence of adverse effects found both in our study and in others was
very low, such effects being local and transient, since the product is neither absorbed by tissues
nor does it enter the bloodstream.

In conclusion, our assessment of the study’s results clearly shows that the use of plant extracts
is an alternative that promotes clinical improvement in those conditions requiring drainage of
retained mucus secretions.

Results of administration”.
Khechinashvili, S.
Therapeutics and Clinical Risk Management,
Suppl.1, 2006. 9-14.

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