Thursday, February 28, 2013

Assessment of a new plant extract-based product in rhinosinusitis.

Assessment of a new plant extract-based product in rhinosinusitis.

In spite of the treatments currently available for the treatment of sinusitis, there is a not insignificant percentage of patients who suffer from complications caused by rhinosinusitis, with relapses and chronification of the process in certain cases.
It is therefore necessary to look for other alternatives that can improve efficacy, reduce symptoms and possible complications, without being associated with side effects.
In recent years, a product has been developed from plant extracts that favours natural secretion from the nasal cavity and paranasal sinuses, thereby clearing the accumulated mucus. The purpose of this study was to analyse the effect of plant extracts on rhinosinusitis in a sample of 11 children and 24 adults.
The results of our study indicate that plant extracts are useful in acute rhinosinusitis.

It is obvious that the more specific a treatment is, the greater the efficacy obtained from its use. This could account, at least in part, for what has happened with the therapies that have been used for the treatment of rhinosinusitis (Barreiro et al. 2002). It is clear to us why there are still recurrences of the disease in our time, with chronification of the condition, which in turn increases the likelihood of complications (Clement et al. 1998; Cohen et al. 2000).
In addition, the treatments routinely used are not without side effects, which renders necessary a process of profound reflection in order to optimise resources (Lopatin 1992; Varonen & Sainio 2004).
This new product with plant extracts activates the physiological nasal drainage mechanisms and facilitates natural secretion, clearing the nasal and paranasal area naturally and effectively.
Our results show the usefulness of this product, both when given alone and with antibiotics and decongestants.
Furthermore, since it is not absorbed by tissues and does not enter the bloodstream, the few side effects that this product may cause in a small percentage of patients are purely local, with no systemic effects. These results are consistent with other studies, which confirm a level of efficacy greater than 90% in relieving the main symptoms of rhinosinusitis, such as improving nasal congestion and breathing, diminishment and/or disappearance of pathological secretions due to its drainage effect, and the disappearance of headache and tenderness, among others(Khechinashvili et al. 2006; Chernisheva & Siniachenko 2006).
In conclusion, it can be said that this new product with plant extracts is highly effective
in obtaining symptom relief in patients with acute exudative rhinosinusitis or acute exacerbations of chronic rhinosinusitis.

Zaritska I.
Therapeutics and Clinical Risk Management,
Suppl.1, 2006. 15 - 17.

Tuesday, February 26, 2013

Use of a new plant extract based product in inflammatory diseases of the paranasal sinuses.

Use of a new plant extract based product in inflammatory diseases of the paranasal sinuses.

The incidence of rhinosinusitis continues to increase year after year, in spite of the therapies
currently available. Although antibiotics have been used extensively for the treatment of rhinosinusitis,
their insufficient efficacy has sometimes contributed to aggravating the problem,
as their indiscriminate use eliminates vital saprophytic flora and leads to the creation of
strains that are resistant to antibiotics. This hasled several authors to reflect on the need for a
more rational use of the medication currently used in the treatment of rhinosinusitis.

In recent years, a product has been developed which, when applied in the nasal cavity, activates
the physiological nasal mucosa clearing mechanisms, promoting natural secretion,
cleansing and drainage of the accumulated purulent content. Our purpose was to analyse
this new plant extract-based product’s effect on rhinosinusitis. Computerised axial tomographies
were obtained from 50 patients. The results of our study indicate that the plant extracts promote effective drainage of the retained secretions in rhinosinusitis, thereby facilitating
symptom relief for the patient.


In spite of the considerable interest that has existed from some years now in the treatment of rhinosinusitis, there still exists a significant percentage of patients who suffer complications, sometimes rendering necessary drainage of the
mucus or even sinus punctures. However, in spite of these treatments, this condition sometimes
becomes chronic, giving rise to severe discomfort for the patient and is the cause of
a significant number of days lost from work or school (Piskunov 1995; Henriksson et al. 1996; Pluzhnikov 2003).

Although various methods are currently available for the treatment of acute suppurative
rhinosinusitis, traditionally the treatments prescribed have sought to eradicate the causal
agents of the inflammation, focusing on removing the suppuration from the sinuses,
combined with treatment with antibiotics and vasoconstrictive antihistamine preparations.
However, the insufficient efficacy associated with these treatments has led to a greater trend
towards relapses and chronification, which in turn has raised the need to continue researching
in this field. In recent years, further data have appeared that confirm the ineffectiveness of
treatment with antibiotics in certain situations (Barreiro et al. 2002). Indeed, by eliminating
the indispensable saprophytic flora and generating resistant bacterial strains, antibiotics
can worsen the problem in certain cases. Furthermore,many of the antibiotics commonly
used today have an immunosuppressive action (Pluzhnikov 2003). This has led several authors
to reflect on the need for a more rational use of the conventional therapy for sinusitis so that
the resources currently available can be used more suitably, given their limited efficacy and
the not insignificant presence of adverse effects (Lopatin 1992; Werk & Bauchner 1998; Turnidge
2001; Varonen & Sainio 2004).

Consequently, the use of a natural product for draining accumulated secretions that also propitiates
relief of the symptoms caused by the congested mucosa may be highly useful. This
new product with plant extracts is effective in draining secretions while it has few side effects.
Our results indicate that its action on the nasal mucosa facilitates a reflex secretion and, by activating
physiological mechanisms, it is able to naturally and effectively clear the retained secretions.
This data has been confirmed in other studies, which showed an efficacy rate greater
than 90% in eliminating the main symptoms of rhinosinusitis (difficulty in nasal breathing,
decrease and/or disappearance of pathological secretions, disappearance of headache and
tenderness, among others) (Zasritskaia et al. 2006; Chernisheva & Siniachenko 2006). Furthermore,
being a natural product, the likelihood of adverse effects and allergic reactions
is minimal. In fact, the incidence of adverse effects found both in our study and in others was
very low, such effects being local and transient, since the product is neither absorbed by tissues
nor does it enter the bloodstream.

In conclusion, our assessment of the study’s results clearly shows that the use of plant extracts
is an alternative that promotes clinical improvement in those conditions requiring drainage of
retained mucus secretions.

Results of administration”.
Khechinashvili, S.
Therapeutics and Clinical Risk Management,
Suppl.1, 2006. 9-14.

Thursday, February 21, 2013

Acute rhinosinusitis in adults

Acute rhinosinusitis in adults

Acute rhinosinusitis is a very common disease. Although several causes have been described for this condition, it is considered that obstruction of the drainage orifices from the paranasal sinuses to the nostrils is the basic cause in the development of this type of condition, both through the retention of secretions, which promotes bacterial growth, and through decreased oxygen supply, which promotes growth of anaerobic germs.

Although a number of treatments have been used for this condition, there a remains a percentage of patients who experience complications caused by rhinosinusitis. In addition, the drugs are also associated with adverse effects.
Administration of certain plant extracts activates the physiological cleansing mechanisms, increasing natural secretion within the sinuses and thereby clearing the purulent content accumulated in the sinuses and relieving the symptoms associated with this disease. We present our experience in the use of a plant extract-based product in 28 patients diagnosed with acute purulent rhinosinusitis.


Our results support the benefit provided by the use of plant extracts in the drainage of secretions in acute rhinosinusitis. These results have been confirmed in other studies of sinonasal diseases and postoperative care (Zasritskaia et al. 2006; Khechinashvili et al. 2006; Chernisheva & Siniachenko 2006).
An appropriate early treatment of the acute rhinosinusitis significantly decreases the need to use antibiotics, which will both reduce costs and the likelihood of side effects (Torralba etal. 2006).
Furthermore, studies analyzing the usefulness of antibiotics in acute sinusitis have shown conflicting results, possibly due to the inclusion of patients with viral rhinosinusitis in these studies.
Indeed, as some recommendations have pointed out, antibiotics should not be used when a viral aetiology is suspected (mild-moderate rhinosinusitis, lasting less than 7 days, no fever or persistent headache) (Engels et al. 2000; Piccirillo et al. 2004).


 With respect to the patient’s symptoms, including nasal congestion, it is important to facilitate rapid drainage of the mucus secretions retained in the sinuses while at the same time minimising the incidence of side effects.  The use of this new plant extract-based product is a significant step forward as it is able to act on the very root of the problem, facilitating rapid and effective drainage of the retained mucus, accompanied by symptom relief in more than 90% of the cases. Furthermore, since it acts locally (it is not absorbed by the tissues and does not enter the bloodstream), there are no major side effects. There may be mild side effects (stinging sensation, sneezing) that do not require stopping treatment. Also, being a natural product and containing no irritants or toxic products, allergy to the product is unlikely to appear. In conclusion, the use of plant extracts provides a rapid, effective and safe alternative.

Summary of studies and conclusions. 
“Use of a new plant extract-based product in acute purulent rhinosinusitis”
Bezshapochny, S.
Therapeutics and Clinical Risk Management,
Suppl.1, 2006. 1-7.

Tuesday, February 19, 2013

Case experience

Case experience  with Cyclamen extract

This case concerns a girl we had been monitoring since she was 10 months old. She was currently 8 years old and had suffered multiple catarrhal conditions. She had undergone surgery on 3 occasions for adenoids and drainage. Her current condition was significant recurrent rhinosinusitis with mucopurulent secretions that had appeared repeatedly over these years and recurrent otitis.


 After administration of cyclamen extract there has been a significant decrease in the purulent secretions from the middle meatus that, until then, had not been cured in spite of multiple treatments with antibiotics, corticoids and mucolytics. At present, she is almost symptom-free.
The usual treatment schedule for cyclamen extract is 1 application per day in each nostril over a 7-day period. In the case we have described of this 8-year-old patient, we have applied 1 dose alternately in each nostril for 2 months. The symptoms improved rapidly but we decided to continue treatment in order to obtain the current outcome in which she is asymptomatic.
On the basis of the experience we are having, my opinion of treatment with cyclamen extract  is decidedly good. The results have been satisfactory in all patients to whom it has been given. I would point out its significant secretion draining power and the fact that within a short period of time, 7 days, the patient’s problem has been solved.

Take it from 

Wednesday, February 13, 2013

Cyclamen Extract precis

Cyclamen  Extract precis

Until now, the usual therapy for rhinosinusitis has included antibiotics, corticoids,
mucolytics, nasal decongestants and/or antihistamines. The primary goal pursued by treatment is to improve the clinical symptoms caused by this condition and, obviously, prevent complications.
Cyclamen extract, is a natural product that is applied topically. It does not cause any significant residual irritation, it does not remain in the nasal cavity and has no systemic effects. The cyclamen extract has a local action on the sinonasal mucosa, triggering a reflex secretion. The product is administered intranasally and its specification is to stimulate physiological mechanisms within the nasal passages and facilitate discharge of these secretions by means of an intense natural drainage of the paranasal sinuses.
In recent years, Cyclamen extract has been developed. It is a natural aqueous solution containing extracts from plants belonging to the Primulaceae family. The plants are growing plantations under climate conditions that guarantee their quality and effectiveness. It is administered topically by spraying into the nasal passages and reduces the symptoms associated with congestive conditions.


 The plant extract activates the physiological clearing mechanisms of the congested airway mucosa, giving rise to a mechanical entrainment effect on the accumulated mucus secretions and facilitating their drainage, cleansing and removal.

How does it act?
After intranasal administration, it acts on the mucosal surface, triggering a reflex secretory response by the mucous membranes lining the nasal passages and paranasal sinuses. shortly after application, the patient may experience smarting and irritation in the nose.
A reflex secretion starts a few minutes after application of the product, which may continue for a couple of hours. This reflex secre-tion decongests the mucosa and opens the osteomeatal complex. An intense physiological drainage of the paranasal sinuses occurs, with effective results in terms of symptom improvement, which becomes significant by the 4th-5th day after starting treatment.



Monday, February 11, 2013

Rhinosinusitis is a health problem with a major social impact

Rhinosinusitis is a health problem with a major social impact

In recent years, rhinosinusitis has become a major health problem and its incidence is steadily increasing throughout the world. Millions of people suffer from this disorder, which has major medical repercussions and a negative socioeconomic impact. However, in spite of its growing negative implications, until a few years ago there were no treatments available that were capable of providing a permanent solution for this disease.

Unsolved problem 
• In the USA: 34.9 cases of Acute Bacterial Rhinosunusitis peryear 
• Growingbacterial resistance in Europe because of wide and not always adequate use of antibiotics 
• Limited facilities of alternative to antibiotic therapies for mild and moderate forms of Acute Rhinosinusitis 
• No good evidence of efficacy in treatments

Normally, antibiotics are the drugs of choice in patients with signs of rhinosinusitis but, paradoxically, many cases are not caused by bacteria. Furthermore, a growing bac­terial resistance to antibiotics has been do­cumented in Europe (and in the rest of the world) due to the – and not always indica­ted – overuse of antibiotics. A paradigmatic example is the growing resistance by Strep­tococcus pneumoniae to the main drugs of choice, with resistance rates in Spain up to 26% against Penicillin, 37% against the Ma­crolides, and almost 40% against the early-generation Cephalosporins.

Thursday, February 7, 2013

Rinosinusitis alternative

Rinosinusitis alternative

Cyclamen extract it can be particularly useful in acute rhinosinusitis, acute exacerbations of chronic rhinosinusitis (provided that the­re are no obstructions in the meatus), sino­nasal postoperative care, and in acute and secretory otitis media.
With the addition to the treatment of products such as Cyclamen extract, a resource that has been known and studied for many centuries and whose formulation has now been standar­dised and clinically assessed, an important step has been taken towards the goal of con­trolling the symptoms of rhinosinusitis and even reversing its natural course, making it easier to cure. In recent years, a large number of studies have been published in medical li­terature that endorse its efficacy and safety and have also provided further insights into its mechanism of action and possible indica­tions in clinical practice.

 It is a natural product that facilitates phy­siological drainage of the sinuses and clean­sing of the nasal and paranasal cavities and middle ear. Antibiotics are not always necessary to treat acute rhinosinusitis. Hen­ce, the importance of distinguishing co­rrectly between viral and bacterial acute rhi­nosinusitis. 
The Cyclamen extract triggers the discharge of retained seromucous secretions, redu­cing/eliminating nasal congestion and tissue oedema (a direct osmotic effect, with the opening of cell pores). It effectively opens nasal spaces, facilitating physiological dra­inage of the sinuses and clearing the nasal and ear cavities.

Monday, February 4, 2013

ENT Questions & Answers III

ENT Questions & Answers III

In order to ensure proper diagnosis and treatment of rhinosinusitis, it is important to follow the international guidelines or consensuses that are currently available and, in our case, our reference is the EPOS consensus. We must base our actions on the dictates of Evidence-Based Medicine, because that is the best way to guarantee quality care based on evidence and not on personal observations. This symposium has shown that we now have enough knowledge and medical resources to offer better management of a highly prevalent disease which has a negative impact on patients’ quality of life.
- According to the consensus documents that are now emerging, what would be the main treatments of choice for rhinosinusitis?
- It depends on whether it is acute or chronic but, in any case, there is a clear trend towards basing therapy on the administration of topical corticoids, restricting the use of antibiotics.
- And what do you think of the possible benefits that could be obtained with administration of this plant extract-based product?
- It is extremely promising, above all because it is a natural product that has interesting properties. It could be very useful as an adjuvant therapy, improving the symptoms associated with rhinosinusitis.
“This new natural alternative may be very helpful in improving the symptoms of acute rhinosinusitis”

- Can we feel hopeful about the new strategies that are been assessed for addressing the health problems caused by rhinosinusitis?
- Yes, without a doubt. For instance, this symposium has analysed the possible benefits that could be brought by the use of a natural product containing plant extracts. The impression one is left with is that it is a tremendously promising product which may be very helpful in improving this disease’s symptoms.
- What evidence is available for this preparation?
- There is an extensive body of experience obtained with a large number of patients, particularly in certain East European countries. The results are very positive. The most important point to make is that it is a very safe product.
- Do you have any personal experience with this product?
- Yes, albeit very limited. Even so, it has helped me understand better how it acts and to see its positive effects for myself.
- So do you think that it is a useful addition to today’s therapeutic armamentarium for the management of rhinosinusitis?
- Yes. It is a medical product that will have virtually no contraindications, which is a significant benefit in itself. It is not a vasoconstrictor, it has no adrenergic effect. It’s worth trying it in certain sinonasal conditions, since its high efficacy brings a rapid and significant symptom relief.
P. Ortega and H. Massegur

57th National Congress of the Spanish

Society of OtorhinolaryngologyGranada, 1 October 2006