Thursday, December 27, 2012

strong scientific support

Nasodren: strong scientific support


Over the years, many studies to prove the efficacy and safety of Nasodren have been conducted, involving around 2,000 patients. Most of these articles have been published and many of them in journals indexed in PubMed.  
Last April, Rhinology (official Journal of the International Rhinologic Society) published the article “Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute rhinosinusitis: a randomized double-blind, placebo controlled trial” by Oliver Pfaar et al. From this study we obtain the following key messages:

  • Nasodren is effective and safe for the treatment of patients with ARS assessed subjectively and objectively.
  • The specific symptom of facial pain/pressure significantly improved after 5 - 7 days treatment with CE. This is important since facial pain/pressure is undoubtedly one of the most severe symptoms affecting the patient’s quality of life in ARS.
  • Endoscopic evaluation showed that mucus oedema/nasal obstruction improved significantly with CE. Improvement (defined as a sum of endoscopy scores of 0) was significantly higher with CE than placebo at the end of the study.
  • Both patients and investigators reported signi­ficantly greater treatment satisfaction with CE than placebo
  • CE is a safe product for the treatment of ARS

In March, another unique and impressive study was accepted for publication in The Laryngoscope, (organ of the American Laryngological, Rhinological and Otological Society): “An exploratory Trial of Cyclamen Europaeum Extract for Acute Rhinosinusitis” by J. Ponikau et al.
The key messages learnt from this study are:
In patients with Acute Rhinosinusitis, Cyclamen extract (Nasodren / Sinuforte):
  • Improves objective outcomes compared to placebo
  • Produces a clinically relevant symptoms improvement
  • Is the only product marketed for Rhinosinusitis that has been tested in this way (CT); other products, such as corticosteroids, antibiotics or decongestants, measure only symptomatic improvement.
The results of these studies have led, as mentioned above, to the inclusion of Cyclamen europaeum, in the EPOS 2012, the European Guidelines on Rhinosinusitis. Therefore, we can claim to possess a unique product for the treatment of this prevalent condition.

References:
Pfaar O, Mullol J, Anders C, Hormann K, Klimek L. Cyclamen europaeum nasal spray, a novel phytotherapeutic product for the management of acute Rhinosinusitis: a randomized double-blind, placebo-controlled trial. Rhinology. 2012 Mar;50(1):37-44. PMID: 22469604
Ponikau J, Hamilos D, Barreto A, Cecil J, Jones S, Manthei S.  An exploratory trial of Cyclamen europaeum extract for acute Rhinosinusitis. Accepted for publication  Laryngoscope, March, 2012. PMID: 22675486

Thursday, December 20, 2012

Review of traditional Chinese formula

Review of traditional Chinese formula Bi Yan Pian

There are several Chinese formulas that improve symptoms-sinus infections, but Bi Yan Pian is one of the most popular ones. The words “Bi Yan Pian” mean “nose inflammation pill.” The National Pharmaceutical Exhibition awarded Bi the “High Quality (Silver Medal) Seal.” The patented formula does not have side effects of antihistamines, such as dry mouth and drowsiness. 


Uses
Bi Yan Pian, the Chinese rhinitis tablet manufactured by Hankow-based Chung Lien Drug Works, helps in relieving symptoms-sinus infections and chronic and acute rhinitis. The tablet treats inflammation and clears nasal channels. The tablet helps in healing headaches secondary to sinusitis. Bi heals sinus congestion due to “wind heat” and “wind cold.”  Bi Yan is also indicated in nasal infections in which discharge resembles pus. Bi is commonly used to treat runny or stuffy nose due to flu and common cold.
Ingredients
According to the Chinese Pharmacopoeia, the principal components of the formula include Fructus Xanthii (Cang Er Zi) and Flos Magnoline Liliflorae (Xin Yi). Other ingredients are Radix Angelicae Dahuricae (Bai Zhi), Radix Platycodi (Jie Geng), Radix Glycyrrbizae (Gan Cao), Herba Asari (Xi Xin) and Herba Ephedra (Ma Huang). However, the composition of the tablets slightly vary from market to market, as, for instance in the European market, Xi Xin and Ma Huang are banned. The tablets sold in the market are thus devoid of these ingredients.
The tablet is also available in natural-food stores and supermarkets across the United States of America. Even acupuncturists sell the tablets and / or tea. The U.S. Food and Drug Administration (FDA), however, stated that Bi is a dietary supplement because it is an herbal formula and herbs cannot heal pathological disorders.
Scientific evidences
Due to very little scientific data supporting its effectiveness, the West doubts medical properties of the formula. For instance, Massachusetts-based Natural Standard Research Collaboration, engaged in evaluation of natural therapies, concluded that in the absence of evidences they could not even grade the formula. On the other hand, in 2009, a study published in the Journal of Alternative and Complementary Medicine stated that Bi Yan Pian tea treats chronic symptoms-sinus infections and severe inflammation of the nasal channels. The study was conducted at Atlanta-based Morehouse School of Medicine. During the study, a small group of patients was given tea containing the 11-herb formula. The researchers observed an improvement in sleep, nasal congestion and headache symptoms.
Although medical community is divided over efficacy of the formula, it is used to treat a number of symptoms. However, presence of some of the banned ingredients in the formula requires a consultation with your doctor before administering it.

Wednesday, December 19, 2012

Which herb helps in treating sinus/ear congestion?

Which herb helps in treating sinus/ear congestion?

Ligusticum porteri (Osha) helps in relieving sinus/ear congestion.

The plant
Ligusticum porteri, a native to the Rocky Mountains, grows at an altitude ranging from 1,970 to 3,500 meters (6,500-11,500 feet) in the mountain bioregion stretching between Mexico and Canada.  The Hispanics call it osha.   The word “osha” is derived from the Spanish word “oso” which means “bear.” Perennial osha belongs to the Apiaceae / Parsley family of plants. Osha bears pink or white flowers during June-August. The fern –like leaves are triangular and dark green. The brown root is furry, oily, spicy and warm. Osha grows in coniferous forests in moist mountainous areas. The plant can be grown from seeds.
The herb root is used in the bear medicines made by the American Indians and several other cultures, whereas the plant is used as forage. The herb has some properties that are similar to that of angelicas but osha acts differently. The herb is source of bitters, glycosides, resins, silicon and volatile oils.


Uses
The herb resins promote expectoration, mitigate inflammation and aid in clearing the lungs. Thus, the herb is used to treat coughs and overcome capillary congestion in catarrh and bronchitis.

The herb is also used for treating allergies to dairy products, excessive mucus, intestinal lymphatic congestion and pancreas problems.
 
The herb is used for depression and atrophy tissue states. The tissue states used in herbal medicines refers to general pathophysiology and physiology.

The herb with anti-inflammatory and carminative properties improves digestion and nervous system because it imparts tone to the adrenal cortex’s glucocorticoid side. Carminative means expelling gas from the intestines and stomach, relieving flatulence.
The herb is also used for the following conditions:
  • Amenorrhea, dysmenorrhea
  • When senses and mind are dull, and mucus congestion causes problems in the bronchial tree and sinuses.
  • Poor cough reflexes and chronic bronchial problems with severe congestion
  • Colds
  • Emphysema
  • Gastroenteritis, colitis
  • Influenza
  • Measles
  • Pharyngitis
  • Retained placenta
  • Silicosis
  • Tuberculosis
  • Upper gastric spasm

How to use it
Extracts of the dried roots or its decoction is administered in the above conditions. Quantity of the dosage depends on the symptoms. Pregnant patients should avoid the abortifacient herb, which means osha may cause abortion. Thus, it is advisable that you consult the doctor before using the herb for sinus/ear congestion or any other condition. You may also find throat sprays and salves containing the herb and osha syrups in the market.

Tuesday, December 18, 2012

Elder flower for sinusitis and earache

Elder flower for sinusitis and earache

Elder flower, the deciduous shrub that is used in both summer and winter, relieves sinusitis and earache.


The plant

The botanical community call it Sambucus mexicana and nigra. The yellow flowers are fragrant. The indigenous European shrub has been admired for its medicinal properties for ages. Our ancestors even believed that it shoos away the witches. Therefore, the Europeans planted the shrub near their houses.
The easy to grow shrub requires sunny area. Well-composted soil is the best choice to plant elder. During spring, you can propagate elder from the stem cuttings. Clip it in winter to check its sprawling growth.
The dark purple berries are a rich source of vitamins C and A. The herb has vulnerary (wound healing), demulcent (pain relieving), anti-inflammatory, anti-catarrhal (relief from the mucous membranes’ inflammation) and alterative (system nourishment and improvement) properties. Elder flower also acts as an expectorant. Kaempferol (antioxidant) and diaphoretic (encourage perspiration production), flavonol glycosides found in the herb, help in relieving fever.
Sambucus nigra is found in Central and North America, North Africa, Western Asia and Europe.  The Africans use it as a medicinal and ornamental plant.



Uses
The flowers are used for tea that heals several symptoms like runny nose, cold, post nasal drip, sore throat, sinusitis and earache.
The flowers are also added to summer drinks like lemonade. The fruits are eaten raw and used to make pies, jams, wines and brandy.
The fruit extracts are used as an antiviral agent, whereas the inner bark has emetic, purgative and diuretic properties.  Both dry and fresh leaves act as purgative.
The flowers act as a decongestant for the mucosa of the respiratory tract and prevent allergies. The anti-catarrhal herb also moderates excessive mucus and create a balance.
The quercetin-rich flowers with anti-inflammatory properties relieve symptoms of hay fever and sinusitis. The quercetin also aids in mitigating cancer activity.
The flowers heal burns, bruises, sunburns and swelling, and soothe and soften the skin. The flowers are also used for a face wash that improves complexion.
The berry syrups and wines have been produced to heal bronchitis, colds and coughs.
The antiviral herb strengthens immune system and protects against flu and fevers.
The flowers tone the throat and nose mucous membranes.
Elder encourages urine production, sweating, and circulation, helping in removing toxics and harmful acids from the body.
The studies concluded that the flowers kill the Herpes simplex virus, facilitating treatment of cold sores or fever blisters.

Monday, December 17, 2012

15 facts that indicate sinusitis and otitis are related

15 facts that indicate sinusitis and otitis are related

Sinusitis and otitis are related because various reviews, research studies and clinical trials have highlighted the following similarities between the two:

  1. Cause of both is Streptococcus pneumonia, Staphylococcus aureus, Moraxella catarrhalis and Haemophilus influenza.
  2. An influenza virus infection may cause both the conditions.
  3. Children are prone to infections of the upper respiratory tract. These infections lead to bacterial problems like sinusitis and otitis media.
  4. Antibiotics are administered in both the conditions.
  5. Although action of azithromycin in treating acute infections of the upper respiratory tract is not completely understood, but the antibiotic is used in the treatment of acute cases of sinusitis and otitis media. In fact, these acute symptoms even resolve spontaneously, requiring no antibiotics.
  6. The studies found out that most of the otitis media and sinusitis infections are due to virus. Thus no need for antibiotics. Moreover, not all the cases of the bacterial infections require antibiotics.
  7. Evidence-based guidelines are in place for management and diagnosis of both the diseases to prevent excess usage of unnecessary medicines and reduce the treatment cost without compromising on the quality and effectiveness.
  8. The use of conjugate penumcoccal vaccine reduced occurrences of pneumococcal otitis media and acute bacterial rhino sinusitis. The pathogens have also changed. Read the full report Acute bacterial rhinosinusitis and otitis media: Changes in pathogenicity following widespread use of pneumococcal conjugate vaccine by Michael S. Benninger.
  9. Acute otitis media and acute bacterial rhino sinusitis are the infections of the respiratory tract. Both are quite common.
  10. Sinusitis as focal sepsis is one of the primary causes of continuous discharge in the patients suffering from chronic otitis media active mucosal disease
  11. The triad of recurrent bronchitis, sinusitis and otitis media is a syndrome that indicates a systemic problem.
  12. Both the disorders commonly occur in childhood.
  13. Otitis Media and Sinusitis in Children Role of Branhamella catarrhalis, the review by Bluestone, Charles D. stated that the recent clinical trials advise for an antibacterial therapy to treat these infections to avoid any complications. Read the review.
  14. Microbiology of acute bacterial sinusitis and acute otitis media is similar.
  15. In view of the above, there is no doubt that sinusitis and otitis are related. In fact, information available about acute otitis media treatment can be applied to the acute bacterial sinusitis treatment. Especially, this extrapolation could be useful in deciding the best antibacterial and antimicrobial therapy.

Friday, December 14, 2012

herbs for sinus congestion

5 Chinese herbs for sinus congestion

In China, herbs are used in two different ways to treat the sinus problems. Firstly, the herbs are used for purifying the blood within the lungs and stomach, dispelling the heat. These herbs are used with the herbs that aid in digestion to clear the paranasal sinuses and passages. Secondly, the herbs mitigate the cold, restoring the healthy blood and ensuring permanent relief. A number of ready to use herbal formulae are available in the market. This article focuses on some of the herbs that improve paranasal sinus symptoms.


  1. The roots of Huang Qin (skullcap, Scutellaria baicalensis) prevent tissue contraction during allergic reactions. The roots contain antioxidants and flavonoids that stimulate the immune system. Scutellaria baicalensis is native of Russia and China. The herb is traditionally used to treat headaches, cancers, inflammation, infections and allergies. The Chinese skullcap is available in powder form. The plant bears purple or blue flowers.

Diabetics should not take the Chinese skullcap without consulting the physician, as it may reduce the level of blood sugar, increasing chances of hypoglycemia. The skullcap can raise the effects of sedatives, such as anticonvulsants and tricyclic antidepressants.
  1. Bai Zhi (Chinese Angelica / wild angelica / Angelica dahurica) is used to clear sinus congestion and infections. The herb is specially relives discomfort caused due to blocked paranasal sinuses located above the eyes. Aka mitigates swelling, clears nasal passages and helps in draining pus secondary to sinus infections. The herb maintains a balance between histamines. The herb is found in China, East Siberia, Japan and Korea. Its roots are used in medicines.

  1. Since ages, Xho Yi Hua, magnolia flower, has been an integral part of traditional Chinese medicine used to relieve sinusitis-induced headaches and clear blocked nasal passages. Xho, known as Magnolia liliiflora in botany, is also used in fragrances.  The plant with white and pink flowers grows in China and North and South America.
  1. The Chinese have been using the Chinese cucumber (Gua Lou / Trichosanthes kirilowii) for treating ailments of the respiratory system since antiquity. The roots and fruits are used for medicines. The herb bears white flowers.

  1. Cang Er Zi (Xanthium fruit / Xanthium sibiricum), grown in China, is used to open blocked nose. Xanthium is used with other herbs to treat chronic naso-sinusitis and allergic rhinitis.
The herbs for sinus congestion may interact with other medicines. So visit the physician and follow the advice to make the most of the selected herbs for sinus congestion.

Thursday, December 13, 2012

What is oxymetazoline?

Oxymetazoline nasal spray 

What is oxymetazoline?

The synthetic adrenergic agonist acts directly and stimulates alpha one and two adrenergic receptors. The vasoconstrictor is also used for the eye drops that treat redness due to contact lens, colds or swimming. The systemic circulation absorbs the agonist. Since the agonist stimulates the receptors present in the sympathetic nervous system (SNS), the nasal passages’ arterioles constrict and dry the mucous membrane.
The spray, a nasal decongestant that narrows the nasal passage blood vessels, relieves sinus pressure and congestion, and nasal discomfort due to hay fever, allergies and colds. However, the patients under 6 years of age should not use the spray without prescription. Supervision is required in case the patients belong to the 6-12 age group.





Side effects
The spray has some side effects too. For instance, the spray may cause
  • addiction
  • burning,
  • dizziness,
  • dryness within the nose,
  • headache,
  • increase in nasal discharge,
  • nausea,
  • nervousness,
  • sleep problems,
  • sneezing and
  • stinging.
Sometimes the spray may increase or decrease the heartbeat. In such situations, see the physician at the earliest.


How to use it
  • The spray should not be administered more than twice in 24 hours.
  • Read the prescription and / or instructions on the label of the spray. If the instructions are not clear to you, do consult the physician or the pharmacist.
  • The amount of spray used should neither be more than the quantity prescribed by the physician nor less. If you do not follow the physician’s recommendations for the spray quantity and duration, sinus pressure and other symptoms may exacerbate.
  • Stop using the spray after three days. If symptoms do fade, consult the physician.
  • Liquid / solution of oxymetazoline is sprayed into the patient’s nose.
  • Do not gulp the spray. Just use it for the nose.
  • Wash the spray dispenser tip nicely after every use. The same dispenser should not be used by more than one patient to avoid spread of the infection.
  • If you are allergic to oxymetazoline, inform your physician.
  • Since some medicines may interact with the spray, tell your physician about the medicines you are taking for any other ailment. The expectant and breast feeding ladies should not use the spray without consulting the physician.

Wednesday, December 12, 2012

Chronic sinus congestion and chronic dysbiosis

Chronic sinus congestion and chronic dysbiosis

These chronic conditions are related. Chronic dysbiosis in the sinuses and small intestine may cause chronic sinus congestion. In many cases, antibiotics administered to chronic sinus congestion fail and lead to dysbiosis of the intestine.




What is dysbiosis?
Dysbiosis, a common disorder, means harmful growth of intestinal flora and the consequent imbalance. Dysbiosis affects metabolism and create disturbance in gastrointestinal (GI) tract. It also causes behavioral, neurologic and cognitive problems, asthma, allergies and autoimmune problems.
Forms of dysbiosis
In small intestine, dysbiosis involves fermentation i.e. indigestion of carbohydrates that produces alcohol, gases and sugars. In large intestine, dysbiosis is referred to as putrefactive which means indigestion of animal proteins and fats that produces alcohol, gases and sugars. Both fermentation and putrefactive forms of dysbiosis lead to metabolic toxicity.
Candidiasis, a type of dysbiosis, involves excessive growth of Candida albicans, a type of yeast. The yeast is generally found in the mucous membranes of the sinus cavity, urinary tract, vagina and gastrointestinal region. Small amount of Candia is not harmful. However, when Candida level grows beyond the normal healthy level it produces toxins that cause problems.  Chronic candidiasis causes various ailments, including sinusitis, post nasal drip and skin problems.
Causes of dysbiosis
  • Changes in acid-alkaline ratio (pH) in gastrointestinal (GI) tract
  • Chronic stress
  • Excessive consumption of alcohol, grains and sugar
  • Additives used in food
  • Overdose of antibiotics
  • Use of birth control drugs
  • Herbicides, pesticides, preservatives, solvents and other chemicals
  • Exposure to heavy metal and radiation and chemotherapy
  • Bacteria H. pylori that causes ulcer
  • Use of pain relievers such as corticosteroids and antacids

Treatment
Treatment of dysbiosis depends on the form and symptoms. The treatment may include removal of toxins and allergens, replacement of acid, bile and enzymes, use of prebiotics and probiotics, mitigation of inflammation and strengthening immune system. A probiotic is a tablet or food containing beneficial bacteria that improves your health. Prebiotics, non-digestible food, encourages growth of harmless micro-organisms. Consult your doctor for the best therapy.

Tuesday, December 11, 2012

Basil for sinus congestion

Basil for sinus congestion

Basil, a culinary herb, is known as Saint Joseph’s Wort in English-speaking regions. One of the favorite herbs of Greeks and Romans, basil is also regularly used in the Asian and Italian food. Botanists call it Ocimum basilicum.



The plant
The annual plant, a native of India, is used to decorate temples in the country. Holy variety of basil grown in India is called Ocimum sanctum.
The herb, susceptible to frost, grows well in sunny locations with some shade. You can sow the seeds in large containers.
Basil attracts butterflies. So if you like butterflies plant it in your garden and enjoy its multifold benefits.

Uses
The versatile herb, known for more than forty centuries, is used for cooking, cosmetics and medicines. Spicy and pungent scent of the herb enhances flavor of food. For example, it improves taste of vegetables such as marrows, brinjals and courgettes. You can use its oil, powder, paste and or fresh leaves. Ayurveda and Siddha doctors use it for its medicinal properties.
Leaves and seeds are used for cooking. Basil is used with mint, parsley and celery in cooking. Basil also goes well with tomatoes. The herb is an excellent salad dressing.
Dry it in summer and use the powder to garnish food in winter.
Italians use the herb in famous pesto sauce.
You can burn dry basil to keep mosquitoes at the bay.
The African tribes believe that basil leave paste encourages hair growth.
The herb aids in digestion. It gives relief from nausea. Apply fresh basil leaves to the temples to heal headaches.
To heal infections of the mouth, gargle with the herb. Add basil leaves in boiling water for gargle.
Basil leaves offer relief from the pain in heels due to standing for a long time.
A combination of basil, fennel and rosemary is used for lung disorders like asthma and bronchitis.
Add fresh basil leaves in hot water and inhale the steam / vapors to ease sinus congestion.
The herb has antimicrobial, antibacterial and antiseptic properties.
Basil strengthens immune system and cleans the system and thereby protects you against all kinds of diseases and infections including sinus congestion and infections.
The herb, named after serpent-like animal Basilisk that carried deadly poison, was used as an antidote to poison. It was believed that just a gaze of the animal could kill.

 

Monday, December 10, 2012

Topical decongestants

Topical decongestants

Topical decongestants, highly effective vasoconstrictors, offer quick relief from swelling of the mucous membranes and nasal congestion. The most commonly used topical decongestants include xylometazoline, tetrahydrozoline, phenylephrine, naphazoline and epinephrine. These are used to treat symptoms of common cold, rhinitis and sinusitis.  Phenylephrine, used in both systemic and topical decongestants, is one of the common sinus decongestants.
Composition of topical decongestants
Topical decongestants contain sympathomimetic amines and their derivatives, and propylhexedrine. A sympathomimetic drug imitates the central nervous system actions. An amine is a compound containing ammonia. Sympathomimetic amines include epinephrine and phenylephrine. The derivatives of sympathomimetic amines include naphazoline, oxymetazoline and tetrahydrozoline are.


Phenylephrine is a principal component of many nasal drops and sprays.
Naphazoline is used for ophthalmic and nasal solutions. The solutions are available in prescription and over-the-counter (OTC) forms. The ocular solution treats itching and irritation in the eyes. The nasal drops relieve the congestion.
Oxymetazoline, a nasal spray, is sold as OTC. It is also used in ocular drops that reduce redness in the eyes.
 Tetrahydrozoline, a nasal decongestant, is a prescription drug.
How a topical decongestant works
A topical decongestant stimulates alpha-adrenergic receptors present in the nasal blood vessels’ muscle, reducing blood flow to the nose. Pharmacokinetics of the topical decongestant is different than that of systemic. Topical constricts the arterioles by directly acting on the receptors found in the nose muscle. The direct action ensures that only a small quantity of the decongestant is absorbed. Less absorption minimizes the chances of drug interactions. However, it interacts with monoamine oxidase (MAO) inhibitor, causing hypertension and severe headache. If used with a beta blocker, hypertension and bradycardia may occur. When used with methyldopa, the pressor response increases. Reduction in blood supply and capillary permeability resolve swelling of the membranes. Thus, sinus drainage improves, nasal passages become clear and the Eustachian tubes open.
When to use topical decongestants
  • The topical sinus decongestants are used with acute rhino sinusitis treatment for reducing edema and improving drainage of the infected sinus. However, scientific research studies did not show any improvement on use of these decongestants. Thus, their use in acute rhino sinusitis is still controversial.

  • Overuse of topical decongestants causes rebound congestion. So follow the prescription.
  • The sinus decongestants may also provide some relief in the patients suffering from sinus barotraumas.

  • Topical decongestants are also used to control epistaxis.

Thursday, December 6, 2012

3 types of endonasal frontal sinus drainage procedures

3 types of endonasal frontal sinus drainage procedures

There are three types of endonasal frontal sinus drainage techniques: simple frontal sinus drainage (Type I), extended frontal sinus drainage (Type II) and median drainage (Type III).
Simple frontal sinus drainage (Type I)


This technique is indicated when the frontal sinus is opacified or unopacified in the patients suffering from pansinusitis. The patients neither have asthma nor aspirin hypersensitivity. They have not undergone a surgery. In terms of radiology and pathology, the frontal sinus disorder is mild. Other indications include orbital and endocranial complications due to a failed conservative surgery for acute sinusitis, and chronic sinusitis without polyposis.
The Type I operation is combined with endonasal pansinus operation or circumscribed ethmoidectomy.
Extended frontal sinus drainage (Type II)
The type II procedure is used to treat chronic pansinuistis if the large frontal sinus is opacified. If polyposis is not severe but more drainage is required, extended drainage procedure is recommended. The technique is also preferred in case of recurrent barotraumas and frontal sinus examination after circumscribed trauma that affected the ethmoid sinuses’ part located close to the infundibulium.
The type II operation coupled with an endonasal ethmoidectomy can remove small benign tumors like fibrous dysplasia, osteofinromas and osteomas.
Median drainage (Type III)
The technique is used to remove the frontal bone’s anterior beak, frontal intersinus septum and septum top. The removal opens the frontal recesses and facilitates a central drainage pathway. The type III drainage provides the maximum possible endonasal drainage to the nasal cavities from the frontal sinus.
The type III is recommended for pansinusitis that meets the following criteria:
  • The frontal sinus is opacified.
  • Symptoms of underlying diseases like Woakes syndrome, Kartagener syndrome and mucoviscidosis
  • The patients have bronchial asthma and aspirin intolerance.
The operation is also useful if the frontal sinuses are very big, mucosal pathology of the sinus is severe, or all the sinuses feature polyposis. However, it should be avoided if the frontal sinuses are small.
Other indications include intracranial and orbital complications that originate in the frontal sinus mucoceles and the sinuses but without any bone damage. Small benign mid line tumors can also be removed during this type of surgery.
Which is the best procedure?
While selecting the most suitable sinus drainage procedure, keep in mind the following points:
  • Extent and severity of pathology
  • Patient specific anatomy
  • Current outflow from the sinus

Wednesday, December 5, 2012

2 plant oils that enhance sinus infection remedies’ range

2 plant oils that enhance sinus infection remedies’ range

There is a broad spectrum of sinus infection remedies, including plant oils. A number of research studies proved that natural concentrated plant oils kill unfriendly bacteria and ease inflammation of the paranasal sinuses and drain the mucous from both nasal passages and sinuses. This article focuses on two such oils.

Eucalyptus oil

Eucalyptus has astringent, antiviral, antibacterial and antifungal properties. Eucalyptus oil is one of the most commonly used plant oil to clear the sinuses. The oil liquefies the mucous, facilitating drainage of the mucous, healing of the sinus infections and opening up of the sinus channels. The oil kills pathogens and resolves inflammation and strengthens the immune system.

Add the oil in the water used for steam inhalation to clear sinuses and nasal passages. Inhaling eucalyptus vapor is safe and an age old remedy. Many commercially available decongestant rubs also feature eucalyptus oil. However, Eucalyptus is ineffective in case of viral sinusitis.

Since ages eucalyptus has been used to treat sinusitis, sore throat, cough and runny nose due to its decongesting, antioxidant and anti-inflammatory properties. In 2004, Laryngoscope published a study that revealed that eucalyptus eases inflammation of the paranasal sinuses.

Myrtle oil

Myrtle, an evergreen plant found in Mediterranean region, has shiny green leaves that are a storehouse of oil. The plant bears white flowers. The beautiful plant grows well in shade. Myrtle is cherished as symbol of chastity and innocence.

Myrtle oil, concentrated oil that is popular in Europe, has antiseptic, anti-inflammatory and anti-bacterial properties.  

Myrtle, an expectorant, aids in treating sinus infections, bronchitis and colds.

The oil can be used for massage and / or as an air spray.

The oil has cosmetic uses as well. For example, perfumes industry uses it.

1,8 cineole

Both myrtle and eucalyptus feature 1,8 cineole, a compound that stimulates cilia within the sinus cavities, enabling mucous movement and drainage, and aids in opening the blocked sinuses.

Cineole is also called eucalyptol that is main component of the eucalyptus oil. A study stated that cineole may reduce dosage of antibiotics for the sinusitis patients. However, cineole may irritate the stomach membrane, so caution is required while using it. Another research study concluded that cineole reduces discomfort due to non-purulent rhino sinusitis.

How to select plant oils

Look for Bio-Typed oils that are packed in soft get capsules. Bio-Typed oils mean that the product is tested for its effectiveness, purity and safety using advanced technology. There are hundreds of types of eucalyptus, but all eucalyptus trees are not included in the sinus infection remedies.

Tuesday, December 4, 2012

Review of sinus cures

Review of sinus cures

MarketResearch.com released Sinusitis - Pipeline Review, H2 2012 and Sinusitis Global Clinical Trials Review, H1, 2012 reports in 2012.

Sinusitis - Pipeline Review, H2 2012 by Global Markets Direct
The report reviews existing and the latest developments in the global paranasal sinus cures market. The information is collated from various sources, such as third-party documents focusing on the disease, universities and companies’ press releases, investors’ documents, SEC filings of the companies and global databases. 



What does it contain?
  • The report, a comprehensive source of information about sinusitis therapeutics, offers information about an array of sinusitis products that are being developed by universities, research institutes or companies.  The product appraisal covers different development stages ranging from discover to registration.

  • Drug profiles consist of product description and mechanism, and progress in research and development. The report profiled Bacitracin, Levofloxacin vibrENT, Lidocaine + Adrenaline, Pulmozyme, SinuNase and Xolair.
  • The review includes role of major players in advancement of sinus cures. The contribution of Accentia Biopharmaceuticals, Inc., Clarassance, Inc., PARI Pharma GmbH and GlaxoSmithKline plc to sinusitis therapeutics is discussed in the report.
  • The document even covers projects that have been discontinued or are in the late-stage.
Reasons to read it
  • To learn about business deals and new products
  • To understand strategies of the emerging players that are developing highly effective products and gain a competitive edge
  • To develop effective out-licensing and in-licensing strategies
  • Important market and pipeline information will help in selecting the most suitable partner for business expansion by acquiring promising companies and / or merging with related businesses. Get the report.
Sinusitis Global Clinical Trials Review, H1, 2012 by GlobalData
The report offers information and statistics on clinical trials focusing on sinusitis drugs. The document is based on in-house evaluation, secondary and primary research and proprietary databases.
What does it contain?
  • Number of trials conducted in Asia-pacific, Africa, Middle-East, Europe and Americas
  • Status of recruitment for the trial, the sponsors, trial phases
  • A list of suspended, terminated and withdrawn trials
  • Major companies involved in the trials for sinusitis therapeutics
  • Profiles of clinical trials
  • Overview of clinical trials by major players, such as Acclarent, Inc., Bayer AG, Pfizer, Inc., Entellus Medical, Inc. and Sanofi

Reasons to read it
This abridged version of sinusitis related clinical trials being conducted in different parts of the world provides insight into the drug scenario. The latest therapeutics market information will aid in business decisions. Get the report.

Monday, December 3, 2012

Does monotherapy heal swollen sinuses and other symptoms of sinusitis?

Does monotherapy heal swollen sinuses and other symptoms of sinusitis?

Monotherapy means treating a disorder with a single drug. Does monotherapy heal swollen sinuses and any other signs and symptoms of sinusitis? There is no definite answer to this question, as different research studies have arrived at different conclusions. The results of a few such studies are summarized in the article.


Systemic corticosteroid monotherapy for clinically diagnosed acute rhino sinusitis: a randomized controlled trial by Roderick P. Venekamp, et al concluded that the monotherapy did not show any clinically relevant improvement in the patients. During December 2008-April 2011, the placebo-controlled, double-blind, block-randomized trial was conducted in the Netherlands. Read the report.
The efficacy of sinuforte in the starting monotherapy of the patients presenting with acute rhino sinusitis, a randomized open study, by Semenov VF and Banashek-Meshcheriakova TV showed that the 73% patients felt better after monotherapy. The study was conducted on the patients suffering from a moderate level of acute suppurative rhino sinusitis. Get more information.

In the article Efficacy and safety of mometasone furoate nasal spray in the treatment of sinusitis or acute rhino sinusitis, Klossek JM highlighted results of a placebo-controlled, double-blind randomized study on adult patients with uncomplicated acute sinusitis. The study compared mometasone furoate as nasal spray (MFNS) monotherapy and an antibiotic therapy. The study showed that the patients given MFNS monotherapy experienced more improvement in the symptoms than the patients who received an antibiotic therapy. Klossek concluded that MFNS has an important role to play in acute sinusitis treatment. MFNS may be used as monotherapy or with antibiotics. Get more information.
Some studies revealed that Nasodren®, nasal spray by Hartington Pharmaceutical, S.L.U. can be used as monotherapy or in combination with other therapies to treat acute rhino-sinusitis. Read complete results.
The randomized study New perspective in non-invasive treatment to sinusitis was conducted in various centers by Kirukov, et al. The study tested safety and efficacy of sinuforte monotherapy in sinusitis patients. The study showed that the monotherapy is safe and effective for treating exudative sinusitis of moderate to mild severity. Read the study.
The role of Stenotrophomonas maltophilia in refractory chronic rhino sinusitis by Grindler, et al stated that the monotherapy with fluoroquinolones or TMX is effective in the patients of refractory chronic rhino sinusitis (CRS). Stenotrophomonas maltophilia, a gram-negative bacillus that is drug-resistant, may cause refractory CRS. Read the complete report.
A monotherapy or a combination of therapies is a physician’s decision. However, treating swollen sinuses is necessary because it can affect drainage and cause congestion, leading to discomfort.