Monday, July 16, 2012


Pharmacological sinusitis treatments

These are indicated in situations with pain and inflammation of the sinusoids. They improve symptoms but not the disease.

How do they work?
Acetyl salicylic acid: it produces analgesia by blocking the synthesis of prostaglandins mediated by the inhibition of cyclooxygenase.Paracetamol: It peripherally blocks pain impulses through the reversible inhibition of cyclooxygenase, the enzyme that intervenes in the synthesis of the prostaglandins.Ibuprofen: Non-steroidal anti-inflammatory (NSAIDs) belonging to the group of the arylpropionic acids, which act by preventing the synthesis of prostaglandins.
What should be recommended for their proper use?:
  • Do not treat for more than 10 days.
  • Alcoholic drinks should not be ingested.
  • The recommended therapeutic doses should not be exceeded in any of the three.


Paracetamol: in orally disintegrating form, it can be dissolved directly in the mouth or with a little milk or water (not in fruit juice).
Acetylsalicylic acid: the orally disintegrating forms can be dissolved directly in the mouth, it is not necessary to drink liquids. The other forms must be taken with milk, water or fruit juices.Ibuprofen: All the oral forms, even the orally disintegrating ones, must be taken with water, milk or fruit juice.

What situations may give rise to problems related to these medicinal products?
  • The use of aspirin and ibuprofen is contraindicated in patients that have had asthmatic crises.
  • In prolonged aspirin and ibuprofen treatments, the patient should be monitored carefully to detect possible signs and symptoms of ulcers or gastrointestinal haemorrhage.
  • Paracetamol should be monitored due to its possible hepatotoxicity.
  • Adverse effects include nausea, gastric acidity, dyspepsia, urticary and exanthematic reactions.
  • Patients with hypertension should be monitored if treated with acetyl salicylic acid or ibuprofen.

Do these drugs interact with other medicinal products?
Acetyl salicylic acid and ibuprofen:
  • The administration of two or more NSAIDS can increase the risk of peptic ulcer.
  • When administered with oral anticoagulants, they may cause haemorrhages.
  • The simultaneous administration of ibuprofen-aspirin may reduce the antiplatelet properties of aspirin.
  • When administered with certain medicinal products, such as corticosteroids, the risk of gastric haemorrhages is increased.
  • Interactions with antihypertensive drugs.
Paracetamol: As this is metabolised through the liver, it may interact with medicinal products that are metabolised through this same route of elimination.

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