Friday, June 22, 2012

CYCLAMEN EXTRACT

Non-pharmacological sinusitis treatment


How does it work?
The aqueous extract obtained from the Cyclamen europaeum root-tuber is rich in saponins. These substances are known for their surfactant activity, which means they are adsorbed through the nasal mucosa without being absorbed into the bloodstream.




The surfactant action of the cyclamen saponins on the nasal mucosa reduces surface tension, facilitating humidification of the zone in addition to the secretion of mucin by goblet cells. This fluidifies the mucous accumulated in the nasal cavity, facilitating its elimination and thereby relieving congestion.
In addition, the saponins stimulate the sensitive receptors present in the nasal mucosa, inducing a nociceptive response transmitted by the trigeminal nerve. The nasal mucosa is entirely innervated by the trigeminal nerve, and therefore the cholinergic response generated in the nasal cavity is observed throughout the nasal mucosa, favouring opening of the ostium, increasing glandular secretions and increasing ciliar movement in the entire area. The accumulated secretions in the sinuses are consequently drained through the nose, providing rapid symptomatic relief of nasal congestion.

How and when should it be used?
Freeze-dried cyclamen extract must be reconstituted with water before use. Once reconstituted, the product should be refrigerated and can be stored for up to 16 days. It is administered once a day by spraying in each nasal cavity, preferably at night, approximately 2 hours before bedtime. Inhalation should be avoided during application so that the saponins act only on the nasal mucosa.
Treatment lasts 7-10 days, and if necessary this may be extended to up to 14 days.

What is recommended for proper use?
The mucosa should be clean and intact. To apply, hold the head in a vertical position and apply the solution by squeezing the nebuliser once in each nostril without inhaling.
When should this product not be recommended?
• In the case of known allergies to plant extracts, especially those in the Primulacea family.
• In patients with frequent nosebleeds.
• In children under 5 years of age.
• Do not use during pregnancy and nursing.

Does this product interact with medications?
The action of cyclamen extract is local, and it is never absorbed into the bloodstream, so there are no known medication interactions associated with it. This product can be prescribed both as a monotherapy and, if needed, in combined therapy with other medications for treating rhinosinusitis. These include antibiotics, corticosteroids and antihistamines. If use of another nasal spray is required, waiting 2 hours between the two products is recommended.

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