Tuesday, February 14, 2012

Does Nasodren® have an effect similar to that of peppermint?

Does Nasodren® have an effect similar to that of peppermint?


Peppermint, Mentha piperita, comes from the Greek Mintha. There are 25-30 species of Peppermint. Peppermint has different components, among which there are the essential oils like menthol, neomenthol, isomenthol, neoisomenthol, piperitoles, piperitenol, isopiperitenol. The pharmacology of peppermint focuses almost entirely on its menthol components. Peppermint oil vapor is used as an inhalant for respiratory congestion.


Peppermint and menthol are essential oils that are used as an external nasal decongestant, menthol does not objectively decrease nasal decongestion (1-7), in spite of the fact that there is a subjective improvement in the sensation of easier breathing by subjects.


While Nasodren® has had its objective decongestant effect proved by different controlled studies, it offers therapeutically multi-action functions, opening the ostiomeatal complex, and activating the mucociliary system. Consequently, it increases the drainage of mucus retained in the sinonasal area; produces fast dehydration and a detumescent effect (calms and relieves swelling). Unlike other products used in Rhinosinusitis treatment, Nasodren® is not indicated for a specific etiology, but rather aimed at improving the symptomatology regardless of the cause that produces it.


1. Eccles R, Griffiths DH, Newton CG, Tolley NS. The effects of menthol isomers on nasal sensation of airflow. Clinical Otolaryngology & Allied Sciences 1988; 13:25-9.

2. Eccles R, al e. The effects of D and L Isomers of menthol upon nasal sensation of airflow. The Journal of Laryngology and Otology 1988; 102:506-508.

3. Eccles R, Jones AS. The effect of menthol on nasal resistance to air flow. J Laryngol Otol 1983; 97:705-9.

4. Nishino T, Tagaito Y, Sakurai Y. Nasal inhalation of l-menthol reduces respiratory discomfort associated with loaded breathing. Am J Respir Crit Care Med 1997; 156:309-13.

5. Eccles R, Jawad MS, Morris S. The effects of oral administration of (-)-menthol on nasal resistance to airflow and nasal sensation of airflow in subjects suffering from nasal congestion associated with the common cold. J Pharm Pharmacol 1990; 42:652-4.

6. Eccles R, Morris S, Jawad MS. The effects of menthol on reaction time and nasal sensation of airflow in subjects suffering from the common cold. Clin Otolaryngol 1990; 15:39-42.

7. Burrow A, Eccles R, Jones AS. The effects of camphor, eucalyptus and menthol vapour on nasal resistance to airflow and nasal sensation. Acta Otolaryngol (Stockh) 1983; 96:157-61.

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